| http://purl.uniprot.org/citations/34508355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34508355 | http://www.w3.org/2000/01/rdf-schema#comment | "ADP-ribosylation is a modification that targets a variety of macromolecules and regulates a diverse array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases and reversed by ADP-ribosylhydrolases. Recently, an ADP-ribosyltransferase toxin termed 'DarT' from bacteria, which is distantly related to human PARPs, was shown to modify thymidine in single-stranded DNA in a sequence specific manner. The antitoxin of DarT is the macrodomain containing ADP-ribosylhydrolase DarG, which shares striking structural homology with the human ADP-ribosylhydrolase TARG1. Here, we show that TARG1, like DarG, can reverse thymidine-linked DNA ADP-ribosylation. We find that TARG1-deficient human cells are extremely sensitive to DNA ADP-ribosylation. Furthermore, we also demonstrate the first detection of reversible ADP-ribosylation on genomic DNA in vivo from human cells. Collectively, our results elucidate the impact of DNA ADP-ribosylation in human cells and provides a molecular toolkit for future studies into this largely unknown facet of ADP-ribosylation."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkab771"xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/author | "Ahel I."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/author | "Tromans-Coia C."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/author | "Timinszky G."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/author | "Lopes M."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/author | "Moeller G.K."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/author | "Sanchi A."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/pages | "10477-10492"xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/title | "TARG1 protects against toxic DNA ADP-ribosylation."xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/34508355 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34508355 |
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