| http://purl.uniprot.org/citations/34510707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34510707 | http://www.w3.org/2000/01/rdf-schema#comment | "ScopeMost people are vitamin D insufficient around the world. Vitamin D intestinal absorption should thus be optimized. The role of the ATP-binging cassette G5/G8 (ABCG5/G8) heterodimer in vitamin D intestinal efflux is investigated.Methods and resultsBoth cholecalciferol and 25-hydroxycholecalciferol apical effluxes are increased by ABCG5/G8 overexpression in human Griptite cells. Mice deficient in ABCG5/G8 at the intestinal level (I-Abcg5/g8-/- mice) display an accumulation of cholecalciferol in plasma in females and in liver in males compared to control animals. I-Abcg5/g8-/- mice display a delay in cholecalciferol postprandial response after gavage compared with controls. 25-Hydroxycholecalciferol transfer from plasma to lumen is observed in vivo in intestine-perfused mice, and the lack of intestinal ABCG5/G8 complex induces a decrease in this efflux, while vitamin D bile excretion remains unchanged.ConclusionOverall, it is showed for the first time that the ABCG5/G8 heterodimer regulates the kinetics of absorption of dietary vitamin D by contributing to its efflux back to the lumen, and that it also participates in vitamin D transintestinal efflux."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.org/dc/terms/identifier | "doi:10.1002/mnfr.202100617"xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Nowicki M."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Le May C."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Halimi C."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Defoort C."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Reboul E."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Antoine T."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Margier M."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/author | "Svilar L."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/name | "Mol Nutr Food Res"xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/pages | "e2100617"xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/title | "The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine."xsd:string |
| http://purl.uniprot.org/citations/34510707 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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