| http://purl.uniprot.org/citations/34512660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34512660 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8+ T cells are major components of adaptive immunity and confer robust protective cellular immunity, which requires adequate T-cell numbers, targeted migration, and efficient T-cell proliferation. Altered CD8+ T-cell homeostasis and impaired proliferation result in dysfunctional immune response to infection or tumorigenesis. However, intrinsic factors controlling CD8+ T-cell homeostasis and immunity remain largely elusive. Here, we demonstrate the prominent role of Brd4 on CD8+ T cell homeostasis and immune response. By upregulating Myc and GLUT1 expression, Brd4 facilitates glucose uptake and energy production in mitochondria, subsequently supporting naïve CD8+ T-cell survival. Besides, Brd4 promotes the trafficking of naïve CD8+ T cells partially through maintaining the expression of homing receptors (CD62L and LFA-1). Furthermore, Brd4 is required for CD8+ T cell response to antigen stimulation, as Brd4 deficiency leads to a severe defect in clonal expansion and terminal differentiation by decreasing glycolysis. Importantly, as JQ1, a pan-BRD inhibitor, severely dampens CD8+ T-cell immune response, its usage as an anti-tumor agent or latency-reversing agent for human immunodeficiency virus type I (HIV-1) should be more cautious. Collectively, our study identifies a previously-unexpected role of Brd4 in the metabolic regulation of CD8+ T cell-mediated immune surveillance and also provides a potential immunomodulation target."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.728082"xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Pan T."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Song Z."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Qiao Y."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Xia B."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Huang F."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/author | "Peng Z."xsd:string |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34512660 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |