| http://purl.uniprot.org/citations/34516330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34516330 | http://www.w3.org/2000/01/rdf-schema#comment | "Long non-coding RNAs (lncRNAs) emerge as vital modulators and tissue-specific biomarkers of multiple cancers, including gastric cancer (GC). Instead, the expression characteristics, biological function and molecular mechanism of lncRNA PCED1B antisense RNA 1 (PCED1B-AS1) in GC await more elaboration. In this study, 48 cases of GC tissues and matched non-cancerous tissues were collected, and PCED1B-AS1, microRNA-215-3p (miR-215-3p) and C-X-C motif chemokine receptor 1 (CXCR1) expression levels were detected by qRT-PCR. Besides, CCK-8, EdU, Transwell and Western blot assays were conducted to assess the impact of PCED1B-AS1 or miR-215-3p on cell growth, migration, invasion and epithelial-mesenchymal transition (EMT). The interaction between genes was verified by bioinformatics analysis, rna immunoprecitipation (RIP) and dual-luciferase reporter gene assays. We demonstrated that, PCED1B-AS1 expression level was raised in GC tissues and cell lines, and increased expression of PCED1B-AS1 was in association with tumor size, TNM stage and lymph node metastasis in GC patients. Additionally, PCED1B-AS1 overexpression promoted GC cells proliferation, migration, invasion and EMT, and miR-215-3p overexpression counteracted the biological effects of PCED1B-AS1. Mechanistically, PCED1B-AS1 specifically inhibited miR-215-3p expressions, thus up-regulating CXCR1 expressions. In conclusion, PCED1B-AS1 accelerates GC progression via adsorbing miR-215-3p and up-regulating CXCR1, indicating that PCED1B-AS1 is a novel therapeutic target for treating GC."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.org/dc/terms/identifier | "doi:10.1080/21655979.2021.1971503"xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/author | "Zhou R."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/author | "Huang F."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/name | "Bioengineered"xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/pages | "6083-6095"xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/title | "Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis."xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34516330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34516330 |
| http://purl.uniprot.org/citations/34516330 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34516330 |
| http://purl.uniprot.org/uniprot/#_B4DQ59-mappedCitation-34516330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34516330 |
| http://purl.uniprot.org/uniprot/#_P25024-mappedCitation-34516330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34516330 |
| http://purl.uniprot.org/uniprot/#_Q6LCZ9-mappedCitation-34516330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34516330 |
| http://purl.uniprot.org/uniprot/B4DQ59 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34516330 |
| http://purl.uniprot.org/uniprot/Q6LCZ9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34516330 |
| http://purl.uniprot.org/uniprot/P25024 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34516330 |