| http://purl.uniprot.org/citations/34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34525355 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian cell cytoskeletal reorganization for efficient directional movement requires tight coordination of actomyosin and microtubule networks. In this study, we show that LRAP35a potentiates microtubule stabilization by promoting CLASP2/EB1 interaction besides its complex formation with MRCK/MYO18A for retrograde actin flow. The alternate regulation of these two networks by LRAP35a is tightly regulated by a series of phosphorylation events that dictated its specificity. Sequential phosphorylation of LRAP35a by Protein Kinase A (PKA) and Glycogen Synthase Kinase-3β (GSK3β) initiates the association of LRAP35a with CLASP2, while subsequent binding and further phosphorylation by Casein Kinase 1δ (CK1δ) induce their dissociation, which facilitates LRAP35a/MRCK association in driving lamellar actomyosin flow. Importantly, microtubule dynamics is directly moderated by CK1δ activity on CLASP2 to regulate GSK3β phosphorylation of the SxIP motifs that blocks EB1 binding, an event countered by LRAP35a interaction and its competition for CK1δ activity. Overall this study reveals an essential role for LRAP35a in coordinating lamellar contractility and microtubule polarization in cell migration."xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109687"xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/author | "Leung T."xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/author | "Tan I."xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/author | "Chia S."xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/pages | "109687"xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/title | "Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3beta and CK1delta regulates EB1-dependent MT dynamics in cell migration."xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/34525355 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34525355 |
| http://purl.uniprot.org/citations/34525355 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34525355 |
| http://purl.uniprot.org/uniprot/#_Q07A19-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_Q07A20-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_B4DF74-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_B4DG03-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_B3KR06-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_B4DM73-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_E7ERI8-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_O75122-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_Q6N029-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_Q96LR2-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_Q8NB74-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |
| http://purl.uniprot.org/uniprot/#_Q96F87-mappedCitation-34525355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34525355 |