| http://purl.uniprot.org/citations/34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34528727 | http://www.w3.org/2000/01/rdf-schema#comment | "Astrocytes play key roles in regulating multiple aspects of neuronal function from invertebrates to humans and display Ca2+ fluctuations that are heterogeneously distributed throughout different cellular microdomains. Changes in Ca2+ dynamics represent a key mechanism for how astrocytes modulate neuronal activity. An unresolved issue is the origin and contribution of specific glial Ca2+ signaling components at distinct astrocytic domains to neuronal physiology and brain function. The Drosophila model system offers a simple nervous system that is highly amenable to cell-specific genetic manipulations to characterize the role of glial Ca2+ signaling. Here we identify a role for ER store-operated Ca2+ entry (SOCE) pathway in perineurial glia (PG), a glial population that contributes to the Drosophila blood-brain barrier. We show that PG cells display diverse Ca2+ activity that varies based on their locale within the brain. Ca2+ signaling in PG cells does not require extracellular Ca2+ and is blocked by inhibition of SOCE, Ryanodine receptors, or gap junctions. Disruption of these components triggers stimuli-induced seizure-like episodes. These findings indicate that Ca2+ release from internal stores and its propagation between neighboring glial cells via gap junctions are essential for maintaining normal nervous system function."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.org/dc/terms/identifier | "doi:10.1002/glia.24092"xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/author | "Weiss S."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/author | "Littleton J.T."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/author | "Parnas M."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/author | "Ormerod K.G."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/author | "Clamon L.C."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/author | "Manoim J.E."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/name | "Glia"xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/pages | "123-144"xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/title | "Glial ER and GAP junction mediated Ca2+ waves are crucial to maintain normal brain excitability."xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/34528727 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34528727 |
| http://purl.uniprot.org/citations/34528727 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A021WZA4-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6T5-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K715-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K719-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7U9-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K837-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGU9-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6F9-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7K0-mappedCitation-34528727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34528727 |