| http://purl.uniprot.org/citations/34529077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34529077 | http://www.w3.org/2000/01/rdf-schema#comment | "Clustered protocadherins (Pcdhs) are a large family of cadherin-like cell adhesion proteins that are central for neurite self-avoidance and neuronal connectivity in the brain. Their downstream nonreceptor tyrosine kinase Pyk2 (proline-rich tyrosine kinase 2, also known as Ptk2b, Cakb, Raftk, Fak2, and Cadtk) is predominantly expressed in the hippocampus. We constructed Pyk2-null mouse lines and found that these mutant mice showed enhancement in contextual fear memory, without significant change in auditory-cued and spatial-referenced learning and memory. In addition, by preparing Y402F mutant mice, we observed that Pyk2 suppressed contextual fear memory in an autophosphorylation-independent manner. Moreover, using high-throughput RNA sequencing, we found that immediate early genes, such as Npas4, cFos, Zif268/Egr1, Arc, and Nr4a1, were enhanced in Pyk2-null mice. We further showed that Pyk2 disruption affected pyramidal neuronal complexity and spine dynamics. Thus, we demonstrated that Pyk2 is a novel fear memory suppressor molecule and Pyk2-null mice provide a model for understanding fear-related disorders. These findings have interesting implications regarding dysregulation of the Pcdh‒Pyk2 axis in neuropsychiatric disorders."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.org/dc/terms/identifier | "doi:10.1093/jmcb/mjab057"xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Jia L."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Kuang Y."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Cui D."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/author | "Suo L."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/name | "J Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/pages | "808-821"xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/title | "Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner."xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/34529077 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34529077 |
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