| http://purl.uniprot.org/citations/34531288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34531288 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene expression programs controlled by lineage-determining transcription factors are often conserved between species. However, infectious diseases have exerted profound evolutionary pressure, and therefore the genes regulated by immune-specific transcription factors might be expected to exhibit greater divergence. T-bet (Tbx21) is the immune-specific, lineage-specifying transcription factor for T helper type I (Th1) immunity, which is fundamental for the immune response to intracellular pathogens but also underlies inflammatory diseases. We compared T-bet genomic targets between mouse and human CD4+ T cells and correlated T-bet binding patterns with species-specific gene expression. Remarkably, we found that the majority of T-bet target genes are conserved between mouse and human, either via preservation of binding sites or via alternative binding sites associated with transposon-linked insertion. Species-specific T-bet binding was associated with differences in transcription factor-binding motifs and species-specific expression of associated genes. These results provide a genome-wide cross-species comparison of Th1 gene regulation that will enable more accurate translation of genetic targets and therapeutics from pre-clinical models of inflammatory and infectious diseases and cancer into human clinical trials."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.202101075"xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/author | "Herrero J."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/author | "Pullabhatla V."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/author | "de Rinaldis E."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/author | "Henderson S."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/author | "Hertweck A."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/author | "Jenner R.G."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/author | "Lord G.M."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/pages | "e202101075"xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/title | "The Th1 cell regulatory circuitry is largely conserved between human and mouse."xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/34531288 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34531288 |
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