| http://purl.uniprot.org/citations/34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34544869 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the gene for Norrie disease protein (Ndp) cause syndromic deafness and blindness. We show here that cochlear function in an Ndp knockout mouse deteriorated with age: At P3-P4, hair cells (HCs) showed progressive loss of Pou4f3 and Gfi1, key transcription factors for HC maturation, and Myo7a, a specialized myosin required for normal function of HC stereocilia. Loss of expression of these genes correlated to increasing HC loss and profound hearing loss by 2 mo. We show that overexpression of the Ndp gene in neonatal supporting cells or, remarkably, up-regulation of canonical Wnt signaling in HCs rescued HCs and cochlear function. We conclude that Ndp secreted from supporting cells orchestrates a transcriptional network for the maintenance and survival of HCs and that increasing the level of β-catenin, the intracellular effector of Wnt signaling, is sufficient to replace the functional requirement for Ndp in the cochlea."xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2106369118"xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/author | "Hayashi Y."xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/author | "Tian C."xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/author | "Indzhykulian A.A."xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/author | "Chiang H."xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/author | "Edge A.S.B."xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/pages | "e2106369118"xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/title | "Norrie disease protein is essential for cochlear hair cell maturation."xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/34544869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34544869 |
| http://purl.uniprot.org/citations/34544869 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34544869 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J113-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_A0A140LJB0-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_A0A571BE72-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_A0A571BEN3-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPT3-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPX7-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-34544869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34544869 |