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| http://purl.uniprot.org/citations/34552065 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic DNA Mismatch Repair (MMR) involves redundant exonuclease 1 (Exo1)-dependent and Exo1-independent pathways, of which the Exo1-independent pathway(s) is not well understood. The exo1Δ440-702 mutation, which deletes the MutS Homolog 2 (Msh2) and MutL Homolog 1 (Mlh1) interacting peptides (SHIP and MIP boxes, respectively), eliminates the Exo1 MMR functions but is not lethal in combination with rad27Δ mutations. Analyzing the effect of different combinations of the exo1Δ440-702 mutation, a rad27Δ mutation and the pms1-A99V mutation, which inactivates an Exo1-independent MMR pathway, demonstrated that each of these mutations inactivates a different MMR pathway. Furthermore, it was possible to reconstitute a Rad27- and Msh2-Msh6-dependent MMR reaction in vitro using a mispaired DNA substrate and other MMR proteins. Our results demonstrate Rad27 defines an Exo1-independent eukaryotic MMR pathway that is redundant with at least two other MMR pathways."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-25866-z"xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/author | "Putnam C.D."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/author | "Nguyen K."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/author | "Kolodner R.D."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/author | "Li B.Z."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/author | "Bowen N."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/author | "Calil F.A."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/author | "Torres K.A."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/pages | "5568"xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/title | "Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/34552065 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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