| http://purl.uniprot.org/citations/34554241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34554241 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosome segregation in mitosis is orchestrated by the dynamic interactions between the kinetochore and spindle microtubules. Our recent studies show that mitotic motor CENP-E cooperates with SKAP and forms a link between kinetochore core MIS13 complex and spindle microtubule plus-ends to achieve accurate chromosome alignment in mitosis. However, it remains elusive how SKAP regulates kinetochore attachment from lateral association to end-on attachment during metaphase alignment. Here, we identify a novel interaction between Aurora B and SKAP that orchestrates accurate interaction between the kinetochore and dynamic spindle microtubules. Interestingly, SKAP spontaneously phase-separates in vitro via weak, multivalent interactions into droplets with fast internal dynamics. SKAP and Aurora B form heterogeneous coacervates in vitro, which recapitulate the dynamics and behavior of SKAP comets in vivo. Importantly, SKAP interaction with Aurora B via phase separation is essential for accurate chromosome segregation and alignment. Based on those findings, we reason that SKAP-Aurora B interaction via phase separation constitutes a dynamic pool of Aurora B activity during the lateral to end-on conversion of kinetochore-microtubule attachments to achieve faithful cell division."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.org/dc/terms/identifier | "doi:10.1093/jmcb/mjab058"xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Liu D."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Dou Z."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Yao X."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Zhuang X."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Green H.N."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/author | "Zohbi N."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/name | "J Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/pages | "841-852"xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/title | "SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation."xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/34554241 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34554241 |
| http://purl.uniprot.org/citations/34554241 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34554241 |
| http://purl.uniprot.org/uniprot/#_B2RC06-mappedCitation-34554241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34554241 |
| http://purl.uniprot.org/uniprot/#_B4DP18-mappedCitation-34554241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34554241 |