| http://purl.uniprot.org/citations/34555302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34555302 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMatrix metalloproteinases (MMPs) play a crucial role in cancer progression and metastasis, however their role in pediatric Acute lymphoblastic leukemia (ALL) is still unrevealed.MethodsThe diagnostic, prognostic and predictive value of tissue inhibitor of metalloproteinase (TIMP-1), MMP-2, MMP-9 and CD34+CD38-cancer stem cells (CSCs) were assessed in bone marrow (BM) samples of 76 ALL children using Flow Cytometry analysis.ResultsThere was a significant increase in TIMP-1 [1.52 (0.41-10) versus 0.91(0.6-1.12); respectively, p < 0.001], and CSCs CD34+CD38- [1 (0.03-18.6) versus 0.3 (0.01-1.1), p < 0.001] expression in ALL patients compared to controls. While there were no significant differences regarding MMP-2 and MMP-9 expression between the two groups. The sensitivity, specificity, area under curve (AUC) of MMP-2 were (80.3%, 53.3% and 0.568, p = 0.404), and of MMP-9 were (53.9%, 40% and 0.660, p = 0.053). While that of TIMP-1 were (78.9%, 100% and 0.892, p < 0.001), and that of CD34+CD38- CSCs were (78.9%, 73.3% and 0.855, p < 0.001). Increased TIMP-1 expression associated with the high-risk disease (p < 0.001). CD34+CD38- CSCs and MMP-2 overexpression associated with MRD at day-15, increased BM blast cell count at diagnosis and at day-15 (p < 0.05). TIMP-1 overexpression is associated with shorter DFS and OS rates (p = 0.009 and p = 0.048). Multivariate logistic regression analysis showed that both TIMP-1 [OR: 4.224, p = 0.046], and CD34+CD38- CSCs [OR: 6.873, p = 0.005] could be potential independent diagnostic factors for pediatric ALL.ConclusionTIMP-1 and CD34+CD38- CSCs could be possible useful diagnostic markers for pediatric ALL. Also, TIMP-1 is a promising prognostic marker for poor outcome of the patients."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.org/dc/terms/identifier | "doi:10.1080/16078454.2021.1978763"xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/author | "Saleh M."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/author | "Khalil M."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/author | "Ebeid E."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/author | "Kandeel E.Z."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/author | "Abdellateif M.S."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/author | "Madney Y."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/name | "Hematology"xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/pages | "758-768"xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/title | "Role of matrix metalloproteinase MMP-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP-1) in the clinical progression of pediatric acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/34555302 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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