| http://purl.uniprot.org/citations/34560002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34560002 | http://www.w3.org/2000/01/rdf-schema#comment | "The interferon (IFN) pathway is critical for cytotoxic T cell activation, which is central to tumor immunosurveillance and successful immunotherapy. We demonstrate here that PKCλ/ι inactivation results in the hyper-stimulation of the IFN cascade and the enhanced recruitment of CD8+ T cells that impaired the growth of intestinal tumors. PKCλ/ι directly phosphorylates and represses the activity of ULK2, promoting its degradation through an endosomal microautophagy-driven ubiquitin-dependent mechanism. Loss of PKCλ/ι results in increased levels of enzymatically active ULK2, which, by direct phosphorylation, activates TBK1 to foster the activation of the STING-mediated IFN response. PKCλ/ι inactivation also triggers autophagy, which prevents STING degradation by chaperone-mediated autophagy. Thus, PKCλ/ι is a hub regulating the IFN pathway and three autophagic mechanisms that serve to maintain its homeostatic control. Importantly, single-cell multiplex imaging and bioinformatics analysis demonstrated that low PKCλ/ι levels correlate with enhanced IFN signaling and good prognosis in colorectal cancer patients."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.08.039"xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Nakanishi Y."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Patel S."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Cuervo A.M."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Nakanishi N."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Ohira M."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Kinoshita H."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Duran A."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Inghirami G."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Loda M."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Yashiro M."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Arias E."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Linares J.F."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Kasashima H."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Martinez-Ordonez A."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Carelli R."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/author | "Cappelli L."xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/34560002 | http://purl.uniprot.org/core/pages | "4509-4526.e10"xsd:string |