Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/34560104http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34560104http://www.w3.org/2000/01/rdf-schema#comment"

Background

Chronic pruritus, or itch, is common and debilitating, but the neuroimmune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate that the IL-33 receptor (IL-33R) is expressed by sensory neurons. However, whether sensory neuron-restricted activity of IL-33 is necessary for chronic itch remains poorly understood.

Objectives

We sought to determine if IL-33 signaling in sensory neurons is critical for the development of chronic itch in 2 divergent pruritic disease models.

Methods

Plasma levels of IL-33 were assessed in patients with atopic dermatitis (AD) and chronic pruritus of unknown origin (CPUO). Mice were generated to conditionally delete IL-33R from sensory neurons. The contribution of neuronal IL-33R signaling to chronic itch development was tested in mouse models that recapitulate key pathologic features of AD and CPUO, respectively.

Results

IL-33 was elevated in both AD and CPUO as well as their respective mouse models. While neuron-restricted IL-33R signaling was dispensable for itch in AD-like disease, it was required for the development of dry skin itch in a mouse model that mirrors key aspects of CPUO pathology.

Conclusions

These data highlight how IL-33 may be a predominant mediator of itch in certain contexts, depending on the tissue microenvironment. Further, this study provides insight into future therapeutic strategies targeting the IL-33 pathway for chronic itch."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.org/dc/terms/identifier"doi:10.1016/j.jaci.2021.09.014"xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Davidson S."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Hu H."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Liu Q."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Kubo M."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Zhao Y."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Feng J."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Avraham O."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Guo C.J."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Cavalli V."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Kim B.S."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Tamari M."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Gereau R.W."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Ver Heul A.M."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Trier A.M."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Joshita S."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Dehner C."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Alexander-Brett J."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Mack M.R."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Oetjen L.K."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Ford Z.K."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Badic A."xsd:string
http://purl.uniprot.org/citations/34560104http://purl.uniprot.org/core/author"Coble D."xsd:string
▶