| http://purl.uniprot.org/citations/34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34566971 | http://www.w3.org/2000/01/rdf-schema#comment | "Naïve T cells (TN) constitutively recirculate through secondary lymphatic organs (SLOs), where they scan dendritic cells (DCs) for cognate peptide-loaded major histocompatibility complexes (pMHC). Continuous trafficking between SLOs not only enables rapid clonal selection but also ensures TN homeostasis by providing access to prosurvival signals from TCR, IL-7R, and the chemokine receptor CCR7. Inside the lymphoid tissue, CCR7-mediated TN motility is mainly driven by the Rac activator DOCK2, with a separate contribution by a phosphoinositide-3-kinase γ (PI3Kγ)-dependent pathway. Tec tyrosine kinases and the Rac activator Tiam1 constitute prominent downstream effectors of PI3K signaling. Yet, the precise role of Tec kinase versus Tiam1 signaling during CCR7-mediated TN migration and homeostasis remains incompletely understood. Here, we examined the function of the Tec family member interleukin-2-inducible T-cell kinase (Itk) and Tiam1 during TN migration in vitro and in vivo using intravital microscopy. Itk deficiency caused a mild decrease in CCR7-triggered TN migration, mirroring observations made with PI3Kγ;-/- T cells, while lack of Tiam1 did not affect TN motility. In silico modeling suggested that reduced migration in the absence of Itk does not result in a substantial decrease in the frequency of TN encounters with DCs within the lymphoid tissue. In contrast, Itk was important to maintain in vivo homeostasis of CD4+ TN, also in MHCII-deficient hosts. Taken together, our data suggest that Itk contributes to TN migration and survival by integrating chemokine receptor and TCR signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.716405"xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/author | "Stein J.V."xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/author | "Thelen F."xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/author | "Ruef N."xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/author | "Wissmann S."xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/pages | "716405"xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/title | "The Tec Kinase Itk Integrates Naive T Cell Migration and In Vivo Homeostasis."xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34566971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34566971 |
| http://purl.uniprot.org/citations/34566971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34566971 |
| http://purl.uniprot.org/uniprot/#_A0A068BD71-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_A0A068BER6-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B5-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P8F6-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_A1A560-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_E9Q1R7-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_G3UWG2-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_G3UWR9-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_J3QMH1-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_P04227-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |
| http://purl.uniprot.org/uniprot/#_P04228-mappedCitation-34566971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34566971 |