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http://purl.uniprot.org/citations/34568896http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34568896http://www.w3.org/2000/01/rdf-schema#comment"

Background

Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a circulating protein in the transforming growth factor-beta superfamily. We sought to study whether LRG1 might predict risk for all-cause and cause-specific mortality in individuals with type 2 diabetes.

Methods

2012 outpatients with type 2 diabetes were followed for a median of 7.2 years and 188 death events were identified. Association of LRG1 with risk for mortality was assessed by multivariable Cox regression models.

Results

Participants with a higher concentration of LRG1 had an increased risk for all-cause mortality [HR (95% CI), 1.76 (1.03-3.01), 1.75 (1.03-2.98), and 4.37 (2.72-7.02) for quartiles 2, 3, and 4, respectively, compared to quartile 1]. The association remained significant after adjustment for known cardio-renal risk factors including estimated glomerular filtration rate and albuminuria [adjusted HR 2.76 (1.66-4.59), quartile 4 versus 1]. As a continuous variable, a 1-SD increment in LRG1 was associated with 1.34 (1.14-1.57)-fold adjusted risk for all-cause mortality. High plasma LRG1 was independently associated with mortality attributable to cardiovascular disease, infection, and renal diseases. Adding LRG1 into a clinical variable-based model improved discrimination (c statistics from 0.828 to 0.842, P = 0.006) and reclassification (net reclassification improvement 0.47, 95% CI 0.28-0.67) for prediction of 5-year all-cause mortality.

Conclusion

Plasma LRG1 predicts risk for all-cause mortality and mortality attributable to cardiovascular disease, infection, and renal disease independent of known cardio-renal risk factors. It may be a potential novel biomarker to improve risk stratification in individuals with type 2 diabetes."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.org/dc/terms/identifier"doi:10.1093/clinchem/hvab172"xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Liu S."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Lee J."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Liu J.J."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Lim S.C."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Tavintharan S."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Ang K."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Shao Y.M."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Sum C.F."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Gurung R.L."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Tang W.E."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/author"Pek S.L.T."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/name"Clin Chem"xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/pages"1640-1649"xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/title"Association of Plasma Leucine-Rich Alpha-2 Glycoprotein 1 (LRG1) with All-Cause and Cause-Specific Mortality in Individuals with Type 2 Diabetes."xsd:string
http://purl.uniprot.org/citations/34568896http://purl.uniprot.org/core/volume"67"xsd:string
http://purl.uniprot.org/citations/34568896http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34568896
http://purl.uniprot.org/citations/34568896http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34568896
http://purl.uniprot.org/uniprot/#_B4E1I8-mappedCitation-34568896http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34568896
http://purl.uniprot.org/uniprot/#_P02750-mappedCitation-34568896http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34568896
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