| http://purl.uniprot.org/citations/34572530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34572530 | http://www.w3.org/2000/01/rdf-schema#comment | "Maintaining 26S proteasome activity under diverse physiological conditions is a fundamental requirement in order to maintain cellular proteostasis. Several quantitative and qualitative mechanisms have evolved to ensure that ubiquitin-proteasome system (UPS) substrates do not accumulate and lead to promiscuous protein-protein interactions that, in turn, lead to cellular malfunction. In this report, we demonstrate that Arsenite Inducible Regulatory Particle-Associate Protein (AIRAP), previously reported as a proteasomal adaptor required for maintaining proteasomal flux during arsenite exposure, can directly bind arsenite molecules. We further show that arsenite inhibits Psmd14/Rpn11 metalloprotease deubiquitination activity by substituting zinc binding to the MPN/JAMM domain. The proteasomal adaptor AIRAP is able to directly relieve PSMD14/Rpn11 inhibition. A possible metal relay between arsenylated PSMD14/Rpn11 and AIRAP may serve as a cellular mechanism that senses proteasomal inhibition to restore Psmd14/Rpn11 activity."xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.org/dc/terms/identifier | "doi:10.3390/biom11091317"xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/author | "Braunstein I."xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/author | "Stanhill A."xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/author | "Sukenik S."xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/name | "Biomolecules"xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/pages | "1317"xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/title | "An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity."xsd:string |
| http://purl.uniprot.org/citations/34572530 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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| http://purl.uniprot.org/uniprot/Q3UWJ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34572530 |