| http://purl.uniprot.org/citations/34576235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34576235 | http://www.w3.org/2000/01/rdf-schema#comment | "This study examined ceruloplasmin levels in patients with HFrEF, depending on cardiopulmonary exercise testing (CPET) parameters; a correlation was found between ceruloplasmin (CER) and iron and hepatic status, inflammatory and redox biomarkers. A group of 552 patients was divided according to Weber's classification: there were 72 (13%) patients in class A (peak VO2 > 20 mL/kg/min), 116 (21%) patients in class B (peak VO2 16-20 mL/kg/min), 276 (50%) patients in class C (peak VO2 10-15.9 mL/kg/min) and 88 (16%) patients in class D (peak VO2 < 10 mL/kg/min). A higher concentration of CER was found in patients with peak VO2 < 16 mL/kg/min and VE/CO2 slope > 45 compared to patients with VE/CO2 slope < 45 (escectively CER 30.6 mg/dL and 27.5 mg/dL). A significantly positive correlation was found between ceruloplasmin and NYHA class, RV diameter, NT-proBNP, uric acid, total protein, fibrinogen and hepatic enzymes. CER was positively correlated with both total oxidant status (TOS), total antioxidant capacity (TAC) and malondialdehyde. A model constructed to predict CER concentration indicated that TOS, malondialdehyde and alkaline phosphatase were independent predictive variables (R2 0.14, p < 0.001). CER as a continuous variable was an independent predictor of pVO2 ≤ 12 mL/kg/min after adjustment for sex, age and BMI. These results provide the basis of a new classification to encourage the determination of CER as a useful biomarker in HFrEF."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms221810074"xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/author | "Duda S."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/author | "Gasior M."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/author | "Romuk E."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/author | "Rozentryt P."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/author | "Lazar-Poloczek E."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/author | "Wojciechowska C."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/pages | "10074"xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/title | "Ceruloplasmin as Redox Marker Related to Heart Failure Severity."xsd:string |
| http://purl.uniprot.org/citations/34576235 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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