| http://purl.uniprot.org/citations/34583062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34583062 | http://www.w3.org/2000/01/rdf-schema#comment | "Specification of cellular polarity is vital to normal tissue development and function. Pioneering studies in Drosophila and C. elegans have elucidated the composition and dynamics of protein complexes critical for establishment of cell polarity, which is manifest in processes such as cell migration and asymmetric cell division. Conserved throughout metazoans, planar cell polarity (PCP) genes are implicated in disease, including neural tube closure defects associated with mutations in VANGL1/2. PCP protein regulation is well studied; however, relatively little is known about transcriptional regulation of these genes. Our earlier study revealed an unexpected role for the fly Rbf1 retinoblastoma corepressor protein, a regulator of cell cycle genes, in transcriptional regulation of polarity genes. Here we analyze the physiological relevance of the role of E2F/Rbf proteins in the transcription of the key core polarity gene Vang. Targeted mutations to the E2F site within the Vang promoter disrupts binding of E2F/Rbf proteins in vivo, leading to polarity defects in wing hairs. E2F regulation of Vang is supported by the requirement for this motif in a reporter gene. Interestingly, the promoter is repressed by overexpression of E2F1, a transcription factor generally identified as an activator. Consistent with the regulation of this polarity gene by E2F and Rbf factors, expression of Vang and other polarity genes is found to peak in G2/M phase in cells of the embryo and wing imaginal disc, suggesting that cell cycle signals may play a role in regulation of these genes. These findings suggest that the E2F/Rbf complex mechanistically links cell proliferation and polarity."xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cdev.2021.203747"xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/author | "Arnosti D.N."xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/author | "Payankaulam S."xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/author | "Hickey S.L."xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/name | "Cells Dev"xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/pages | "203747"xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/title | "Cell cycle expression of polarity genes features Rb targeting of Vang."xsd:string |
| http://purl.uniprot.org/citations/34583062 | http://purl.uniprot.org/core/volume | "169"xsd:string |
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