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http://purl.uniprot.org/citations/34588752http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34588752http://www.w3.org/2000/01/rdf-schema#comment"

Background

Oral intake is dependent on the gastric ability to accommodate the food bolus. Comparatively, neonates have a smaller gastric capacity than adults and this may limit the volume of their milk intake. Yet, we previously reported that the newborn rat gastric milk volume is greatest after birth and, when normalized to body weight, decreases with postnatal age. Such age-dependent changes are not the result of intake differences, but greater gastric accommodation and reduced emptying rate.

Aim

Hypothesizing that breastmilk-derived adiponectin is the factor regulating gastric accommodation in neonates, we comparatively evaluated its effects on the rat fundic muscle tone at different postnatal ages.

Methods

In freshly dispersed smooth muscle cells (SMC), we measured the adiponectin effect on the carbachol-induced length changes.

Results

Adiponectin significantly reduced the carbachol-stimulated SMC shortening independently of age. In the presence of the inhibitor iberiotoxin, the adiponectin effect on SMC shortening was suppressed, suggesting that it is mediated via large-conductance Ca2+ sensitive K+ channel activation. Lastly, we comparatively measured the newborn rat gastric milk curd adiponectin content in one- and two-week-old rats and found a 50% lower value in the latter.

Conclusion

Adiponectin, a major component of breastmilk, downregulates fundic smooth muscle contraction potential, thus facilitating gastric volume accommodation. This rodent's adaptive response maximizes breastmilk intake volume after birth."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.org/dc/terms/identifier"doi:10.3748/wjg.v27.i33.5566"xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/author"Pan J."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/author"Gauda E.B."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/author"Belik J."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/author"Ivanovska J."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/author"Esemu-Ezewu P."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/pages"5566-5574"xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/title"Adiponectin and the regulation of gastric content volume in the newborn rat."xsd:string
http://purl.uniprot.org/citations/34588752http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/34588752http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34588752
http://purl.uniprot.org/citations/34588752http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34588752
http://purl.uniprot.org/uniprot/#_A0A3B0IT73-mappedCitation-34588752http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34588752
http://purl.uniprot.org/uniprot/#_Q8K3R4-mappedCitation-34588752http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34588752
http://purl.uniprot.org/uniprot/A0A3B0IT73http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/34588752
http://purl.uniprot.org/uniprot/Q8K3R4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/34588752