| http://purl.uniprot.org/citations/34600965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34600965 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary membranous nephropathy (MN) is an autoimmune glomerular disease in which autoantibodies are directed against podocyte proteins. In about 80% of cases the main targeted antigen is the phospholipase A2 receptor 1 (PLA2R1). Anti-PLA2R1 antibodies are mainly immunoglobulin G type 4 (IgG4). However, the antigenic target remains to be defined in 20% of cases. MN can be associated with chronic inflammatory demyelinating polyneuropathy, an autoimmune disease of the peripheral nervous system where a common antigenic target has yet to be identified. To ascertain a possible novel target antigen, we analyzed kidney biopsies from five patients positive for anti-contactin 1 antibodies and presenting with MN combined with chronic inflammatory demyelinating polyneuropathy. Eluted IgG from biopsy sections against contactin 1 and nerve tissue were screened. Western blot revealed contactin 1 expression in normal kidney glomeruli. Confocal microscopic analysis showed the presence and colocalization of contactin 1 and IgG4 on the glomerular basement membrane of these patients. Glomerular contactin 1 was absent in patients with anti-PLA2R1-associated MN or membranous lupus nephritis or a healthy control. The eluted IgG from contactin 1-positive biopsy sections but not the IgG eluted from patients with PLA2R1 MN bound contactin 1 with the main eluted subclass IgG4. Eluted IgG could bind paranodal tissue (myelinated axon) and colocalized with commercial anti-contactin 1 antibody. Thus, contactin 1 is a novel common antigenic target in MN associated with chronic inflammatory demyelinating polyneuropathy. However, the precise pathophysiology remains to be elucidated."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.kint.2021.08.014"xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Larroque C."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Delmont E."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Chauvin A."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Bec N."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Devaux J."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Le Quintrec M."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Lanfranco L."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Taieb G."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Jose B."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Teisseyre M."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Szwarc I."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Rigothier C."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Machet M.C."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Mavroudakis N."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Perrochia H."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Geneste C."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Beyze A."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Concetta C."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/author | "Pernin V."xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/name | "Kidney Int"xsd:string |
| http://purl.uniprot.org/citations/34600965 | http://purl.uniprot.org/core/pages | "1240-1249"xsd:string |