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| http://purl.uniprot.org/citations/34608215 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity can cause a chronic, low-grade inflammation, which is a critical step in the development of type II diabetes and cardiovascular diseases. Inflammation is associated with the expression of glycoprotein nonmetastatic melanoma protein b (Gpnmb), which is mainly expressed by macrophages and dendritic cells. We generated a Gpnmb-knockout mouse line using Crispr-Cas9 to assess the role of Gpnmb in a diet-induced obesity. The absence of Gpnmb did not affect body weight gain and blood lipid parameters. While wildtype animals became obese but remained otherwise metabolically healthy, Gpnmb-knockout animals developed, in addition to obesity, symptoms of metabolic syndrome such as adipose tissue inflammation, insulin resistance and liver fibrosis. We observed a strong Gpnmb expression in adipose tissue macrophages in wildtype animals and a decreased expression of most macrophage-related genes independent of their inflammatory function. This was corroborated by in vitro data showing that Gpnmb was mostly expressed by reparative macrophages while only pro-inflammatory stimuli induced shedding of Gpnmb. The data suggest that Gpnmb is ameliorating adipose tissue inflammation independent of the polarization of macrophages. Taken together, the data suggest an immune-balancing function of Gpnmb that could delay the metabolic damage caused by the induction of obesity."xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-99090-6"xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/author | "Bader M."xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/author | "Qadri F."xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/author | "Nickl B."xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/pages | "19614"xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/title | "Anti-inflammatory role of Gpnmb in adipose tissue of mice."xsd:string |
| http://purl.uniprot.org/citations/34608215 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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