| http://purl.uniprot.org/citations/34610044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34610044 | http://www.w3.org/2000/01/rdf-schema#comment | "Epidemiology and pathogenesis of cardiovascular diseases (CVD) and osteoporosis are strikingly overlapping. This study presents matrix metalloproteinase-9 (MMP-9), as a simple molecular link more consistently associated with the pathophysiology of both osteoporosis and CVD risk factors. 40 adult female rats were randomly distributed into 4 groups [control sham-operated, untreated osteoporosis, carvedilol-treated osteoporosis and alendronate-treated osteoporosis]. After 8 weeks, blood samples were collected to estimate Lipid profile (Total cholesterol, HDL, Triglycerides), inflammatory markers (IL-6, TNF alpha, CRP and NO), and Bone turnover markers (BTM) (Alkaline phosphatase, osteocalcin and pyridinoline). The tibias were dissected to estimate MMP-9 and NF-kB gene expression, OPG, RANKL levels and for histological examination. Induction of osteoporosis resulted in a significant elevation in BTM, inflammatory markers and dyslipidemia. MMP-9 was significantly elevated and positively correlated with BTM, inflammation and dyslipidemia markers. Carvedilol and alendronate exerted a bone preservative role and attenuated dyslipidaemia and inflammation in accordance with their respective effect on MMP-9."xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0258254"xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/author | "Sabry M."xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/author | "Mostafa S."xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/author | "Rashed L."xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/author | "Estaphan S."xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/author | "Kamar S."xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/pages | "e0258254"xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/title | "The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis."xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/34610044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34610044 |
| http://purl.uniprot.org/citations/34610044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34610044 |
| http://purl.uniprot.org/uniprot/#_A6HTX4-mappedCitation-34610044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34610044 |
| http://purl.uniprot.org/uniprot/#_Q9ESE2-mappedCitation-34610044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34610044 |
| http://purl.uniprot.org/uniprot/Q9ESE2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34610044 |
| http://purl.uniprot.org/uniprot/A6HTX4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34610044 |