| http://purl.uniprot.org/citations/34626567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34626567 | http://www.w3.org/2000/01/rdf-schema#comment | "In animals, PIWI-interacting RNAs (piRNAs) silence transposons, fight viral infections, and regulate gene expression. piRNA biogenesis concludes with 3' terminal trimming and 2'-O-methylation. Both trimming and methylation influence piRNA stability. Our biochemical data show that multiple mechanisms destabilize unmethylated mouse piRNAs, depending on whether the piRNA 5' or 3' sequence is complementary to a trigger RNA. Unlike target-directed degradation of microRNAs, complementarity-dependent destabilization of piRNAs in mice and flies is blocked by 3' terminal 2'-O-methylation and does not require base pairing to both the piRNA seed and the 3' sequence. In flies, 2'-O-methylation also protects small interfering RNAs (siRNAs) from complementarity-dependent destruction. By contrast, pre-piRNA trimming protects mouse piRNAs from a degradation pathway unaffected by trigger complementarity. In testis lysate and in vivo, internal or 3' terminal uridine- or guanine-rich tracts accelerate pre-piRNA decay. Loss of both trimming and 2'-O-methylation causes the mouse piRNA pathway to collapse, demonstrating that these modifications collaborate to stabilize piRNAs."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.09.012"xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Gainetdinov I."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Jouravleva K."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Zamore P.D."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Arif A."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Colpan C."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Ozata D.M."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Albosta P."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Vega-Badillo J."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/author | "Cecchini K."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/pages | "4826-4842.e8"xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/title | "Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability."xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/34626567 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34626567 |
| http://purl.uniprot.org/citations/34626567 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34626567 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE08-mappedCitation-34626567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34626567 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG9-mappedCitation-34626567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34626567 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEH9-mappedCitation-34626567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34626567 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEK6-mappedCitation-34626567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34626567 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFB2-mappedCitation-34626567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34626567 |