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http://purl.uniprot.org/citations/34627420http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34627420http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the relationship between hypoxia inducible factor 1 (HIF1α) and Wilms' tumor 1associating protein (WTAP) expression level in t(8;21) acute myeloid leukemia cells.

Methods

The t(8;21) acute myeloid leukemia cell lines, including SKNO-1 and Kasumi-1 were treated by Echinomycin for 24 h, RT-qPCR and Western blot were used to detect the expression levels of WTAP mRNA and the protein. The CoCl 2 was used to induce the hypoxia of the cells for 24 h, the expression levels of HIF1α, WTAP protein were detected by Western blot.

Results

The expression level of WTAP mRNA and the protein in the echinomycin treated group was significantly lower than those in the control group (P<0.01). The expression level of WTAP protein in the CoCl2 treated group was significantly higher than those in the control group (P<0.05).

Conclusion

The inhibition of HIF1-α could down-regulates the expression of WTAP, while the up-regulation of HIF1α could up-regulates the expression of WTAP, which shows that there is a positive correlation of HIF1α and WTAP expression. This result suggesting that HIF1α may be involves in the expression regulation of WTAP gene."xsd:string
http://purl.uniprot.org/citations/34627420http://purl.org/dc/terms/identifier"doi:10.19746/j.cnki.issn.1009-2137.2021.05.009"xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/author"Chen Z."xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/author"Wang L.L."xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/author"Liu D.H."xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/author"Gao X.N."xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/author"Shao Y.L."xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/name"Zhongguo Shi Yan Xue Ye Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/pages"1424-1428"xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/title"[The Relationship between HIF1alpha and WTAP Expression Level in t(8;21) Acute Myeloid Leukemia]."xsd:string
http://purl.uniprot.org/citations/34627420http://purl.uniprot.org/core/volume"29"xsd:string
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