| http://purl.uniprot.org/citations/34633746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34633746 | http://www.w3.org/2000/01/rdf-schema#comment | "Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. We unexpectedly find that PML promotes necroptosis in addition to apoptosis, with Pml-/- macrophages being more resistant to TNF-mediated necroptosis than wild-type counterparts and PML-deficient mice displaying resistance to TNF-induced systemic inflammatory response syndrome. Reduced necroptosis in PML-deficient cells is associated with attenuated receptor-interacting protein kinase 1 (RIPK1) activation, as revealed by reduced RIPK1[S166] phosphorylation, and attenuated RIPK1-RIPK3-MLKL necrosome complex formation. We show that PML deficiency leads to enhanced TNF-induced MAPK-activated kinase 2 (MK2) activation and elevated RIPK1[S321] phosphorylation, which suppresses necrosome formation. MK2 inhibitor treatment or MK2 knockout abrogates resistance to cell death induction in PML-null cells and mice. PML binds MK2 and p38 MAPK, thereby inhibiting p38-MK2 interaction and MK2 activation. Moreover, PML participates in autocrine production of TNF induced by cellular inhibitors of apoptosis 1 (cIAP1)/cIAP2 degradation, since PML-knockout attenuates autocrine TNF. Thus, by targeting MK2 activation and autocrine TNF, PML promotes necroptosis and apoptosis, representing a novel tumor-suppressive activity for PML."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.202052254"xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Chen H.C."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Shih H.M."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Lo Y.H."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Wu Y.H."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Lai M.Z."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Chen I.T."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Hsieh F.Y."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/author | "Lai P.Y."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/pages | "e52254"xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/title | "Promyelocytic leukemia protein targets MK2 to promote cytotoxicity."xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/34633746 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34633746 |
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