| http://purl.uniprot.org/citations/34645830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34645830 | http://www.w3.org/2000/01/rdf-schema#comment | "PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for fertility. piRNAs originate from transposable element (TE) RNAs, long non-coding RNAs, or 3´ untranslated regions (3´UTRs) of protein-coding messenger genes, with the last being the least characterized of the three piRNA classes. Here, we demonstrate that the precursors of 3´UTR piRNAs are full-length mRNAs and that post-termination 80S ribosomes guide piRNA production on 3´UTRs in mice and chickens. At the pachytene stage, when other co-translational RNA surveillance pathways are sequestered, piRNA biogenesis degrades mRNAs right after pioneer rounds of translation and fine-tunes protein production from mRNAs. Although 3´UTR piRNA precursor mRNAs code for distinct proteins in mice and chickens, they all harbor embedded TEs and produce piRNAs that cleave TEs. Altogether, we discover a function of the piRNA pathway in fine-tuning protein production and reveal a conserved piRNA biogenesis mechanism that recognizes translating RNAs in amniotes."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-26233-8"xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Li X.Z."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Sun Y.H."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Du K."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Xie L.H."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Ricci E.P."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Wang R.H."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/author | "Pereira A.A."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/pages | "5970"xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/title | "Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs."xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34645830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34645830 |
| http://purl.uniprot.org/citations/34645830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34645830 |
| http://purl.uniprot.org/uniprot/#_F2YMC1-mappedCitation-34645830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34645830 |
| http://purl.uniprot.org/uniprot/#_D3YWG8-mappedCitation-34645830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34645830 |
| http://purl.uniprot.org/uniprot/#_G3UYS5-mappedCitation-34645830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34645830 |
| http://purl.uniprot.org/uniprot/#_G3X8T0-mappedCitation-34645830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34645830 |
| http://purl.uniprot.org/uniprot/#_Q4VAG4-mappedCitation-34645830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34645830 |