| http://purl.uniprot.org/citations/34647407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34647407 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factors (VEGFs) regulate significant pathways in angiogenesis, myocardial and neuronal protection, metabolism, and cancer progression. The VEGF-B growth factor is involved in cell survival, anti-apoptotic and antioxidant mechanisms, through binding to VEGF receptor 1 and neuropilin-1 (NRP1). We employed surface plasmon resonance technology and X-ray crystallography to analyse the molecular basis of the interaction between VEGF-B and the b1 domain of NRP1, and developed VEGF-B C-terminus derived peptides to be used as chemical tools for studying VEGF-B - NRP1 related pathways. Peptide lipidation was used as a means to stabilise the peptides. VEGF-B-derived peptides containing a C-terminal arginine show potent binding to NRP1-b1. Peptide lipidation increased binding residence time and improved plasma stability. A crystal structure of a peptide with NRP1 demonstrated that VEGF-B peptides bind at the canonical C-terminal arginine binding site. VEGF-B C-terminus imparts higher affinity for NRP1 than the corresponding VEGF-A165 region. This tight binding may impact on the activity and selectivity of the full-length protein. The VEGF-B167 derived peptides were more effective than VEGF-A165 peptides in blocking functional phosphorylation events. Blockers of VEGF-B function have potential applications in diabetes and non-alcoholic fatty liver disease."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbic.202100463"xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Djordjevic S."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Martin J.F."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Parker J."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Frankel P."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Chan A.W.E."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Selwood D.L."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Mota F."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "O'Leary A."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Zachary I.C."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Yelland T."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Hutton J.A."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Fotinou C."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/author | "Patsiarika A."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/name | "Chembiochem"xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/pages | "e202100463"xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/title | "Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1."xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/34647407 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34647407 |
| http://purl.uniprot.org/citations/34647407 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34647407 |
| http://purl.uniprot.org/uniprot/#_A8K9V7-mappedCitation-34647407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34647407 |
| http://purl.uniprot.org/uniprot/#_O14786-mappedCitation-34647407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34647407 |