| http://purl.uniprot.org/citations/34649953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34649953 | http://www.w3.org/2000/01/rdf-schema#comment | "Animals perform a series of actions in a fixed order during ritualistic innate behaviors. Although command neurons and sensory pathways responding to external stimuli that trigger these behaviors have been identified, how each action is induced in a fixed order in response to multimodal sensory stimuli remains unclear. Here, the sexually dimorphic lateral antennal lobe tract projection neuron 4 (lPN4) in male Drosophila melanogaster mediates the expression of a fixed behavioral action pattern at the beginning of the courtship ritual, in which a male taps a female body and then extends a wing unilaterally to produce a courtship song. We found that blocking the synaptic output of lPN4 caused an increase in the ratio of male flies that extended a wing unilaterally without tapping the female body, whereas excitation of lPN4 suppressed the transition from the tapping phase to the unilateral wing extension phase. Real-time calcium imaging showed that lPN4 is activated by a volatile pheromone, palmitoleic acid, whose responses were inhibited by simultaneous gustatory stimulation with female cuticular hydrocarbons, showing the existence of an "AND-gate" for multimodal sensory inputs during male courtship behaviors. These results suggest that the function of lPN4 is to suppress unilateral wing extension while responding to a female smell, which is released by appropriate contact chemosensory inputs received when tapping a female. As the female smell also promotes male courtship behaviors, the olfactory system is ready to simultaneously promote and suppress the progress of courtship actions while responding to a female smell.SIGNIFICANCE STATEMENT Although it has been 80 years since Konrad Lorenz and Niko Tinbergen introduced how multiple acts comprising separate innate behaviors are released in a fixed order according to external stimuli, the neural circuits responsible for such fixed action patterns remain largely unknown. The male courtship behavior of Drosophila melanogaster is a good model to investigate how such a fixed behavioral sequence is determined in the brain. Here, we show that lateral antennal lobe tract projection neuron 4 (lPN4) in D. melanogaster functions as an "AND-gate" for volatile and contact chemosensory inputs, mediating the expression of tapping behaviors before unilateral wing extension during male courtship rituals."xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1168-21.2021"xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/author | "Hirao T."xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/author | "Chida H."xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/author | "Ejima A."xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/author | "Tanaka N.K."xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/pages | "9732-9741"xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/title | "A Sexually Dimorphic Olfactory Neuron Mediates Fixed Action Transition during Courtship Ritual in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/34649953 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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