| http://purl.uniprot.org/citations/34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34655920 | http://www.w3.org/2000/01/rdf-schema#comment | "The local immune microenvironment of the uterus plays an important role in a successful pregnancy. IP-10 (CXCL10) has been extensively studied in many immune-related diseases. However, the immune role of IP-10 in early pregnancy has not been fully recognized. This study mainly investigated the role of pro-inflammatory chemokine IP-10 in pregnancy. The levels of IP-10 and its receptor chemokine receptor 3 (CXCR3) were lower in the decidual tissues of an abortion-prone mice than in normal pregnant mice. Meantime, the expression of IP-10 and CXCR3 was higher in the decidual tissues of early pregnant women than in the endometrial tissues of non-pregnant women. IP-10 promoted the production of interleukin 17 (IL-17) and interferon gamma (IFN-γ), and also promoted the migration and differentiation of uterine decidual T cells to type 1 T helper (Th1) cells and Th17 cells. The abortion rate of early pregnant mice increased but the number of CD49b+, CD11b+, and CD3ε+ cells in the decidual tissues decreased upon treatment with anti-IP-10 antibody. Moreover, anti IP-10 antibody decreased the expression of RANTES but increased the expression of anti-inflammatory cytokines IL-6 and IL-10. A successful pregnancy requires the participation of IP-10. IP-10 participates in formation of the pro-inflammatory immune microenvironment during early pregnancy by regulating the distribution of immune cells and promoting the production of pro-inflammatory cytokines."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2021.09.013"xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/author | "Chai X."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/author | "Yuan W."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/author | "Ding H."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/author | "Huang F."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/pages | "59-69"xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/title | "The role of IP-10 and its receptor CXCR3 in early pregnancy."xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://purl.uniprot.org/core/volume | "140"xsd:string |
| http://purl.uniprot.org/citations/34655920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34655920 |
| http://purl.uniprot.org/citations/34655920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34655920 |
| http://purl.uniprot.org/uniprot/#_O88410-mappedCitation-34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/#_Q3U6X5-mappedCitation-34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/#_P17515-mappedCitation-34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/#_Q3UCV1-mappedCitation-34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/#_Q3UK71-mappedCitation-34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/#_Q548V9-mappedCitation-34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/#_Q3UAS6-mappedCitation-34655920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/Q3U6X5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34655920 |
| http://purl.uniprot.org/uniprot/Q3UK71 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34655920 |