| http://purl.uniprot.org/citations/34666001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34666001 | http://www.w3.org/2000/01/rdf-schema#comment | "Surface receptors of animal cells, such as integrins, promote mechanosensation by forming clusters as signaling hubs that transduce tensile forces. Walled cells of plants and fungi also feature surface sensors, with long extracellular domains that are embedded in their cell walls (CWs) and are thought to detect injuries and promote repair. How these sensors probe surface forces remains unknown. By studying the conserved CW sensor Wsc1 in fission yeast, we uncovered the formation of micrometer-sized clusters at sites of force application onto the CW. Clusters assembled within minutes of CW compression, in dose dependence with mechanical stress and disassembled upon relaxation. Our data support that Wsc1 accumulates to sites of enhanced mechanical stress through reduced lateral diffusivity, mediated by the binding of its extracellular WSC domain to CW polysaccharides, independent of canonical polarity, trafficking, and downstream CW regulatory pathways. Wsc1 may represent an autonomous module to detect and transduce local surface forces onto the CW."xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2021.09.024"xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/author | "Sanchez Y."xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/author | "Diaz C.M."xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/author | "Minc N."xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/author | "Celador R."xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/author | "Neeli-Venkata R."xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/pages | "2856-2870.e7"xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/title | "Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast."xsd:string |
| http://purl.uniprot.org/citations/34666001 | http://purl.uniprot.org/core/volume | "56"xsd:string |
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