| http://purl.uniprot.org/citations/34685626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34685626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34685626 | http://www.w3.org/2000/01/rdf-schema#comment | "The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rapidly. While there are structures of some SARS-CoV-2 proteins in complex with antibodies, which helps us understand how the immune system is able to recognise this new virus; however, we lack data on how T cells are able to recognise this virus. T cells, especially the cytotoxic CD8+ T cells, are critical for viral recognition and clearance. Here we report the X-ray crystallography structure of a T cell receptor, shared among unrelated individuals (public TCR) in complex with a dominant spike-derived CD8+ T cell epitope (YLQ peptide). We show that YLQ activates a polyfunctional CD8+ T cell response in COVID-19 recovered patients. We detail the molecular basis for the shared TCR gene usage observed in HLA-A*02:01+ individuals, providing an understanding of TCR recognition towards a SARS-CoV-2 epitope. Interestingly, the YLQ peptide conformation did not change upon TCR binding, facilitating the high-affinity interaction observed."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells10102646"xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells10102646"xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Smith C."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Smith C."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Nguyen A.T."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Nguyen A.T."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Riboldi-Tunnicliffe A."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Riboldi-Tunnicliffe A."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Jayasinghe D."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Jayasinghe D."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Grant E.J."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Grant E.J."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Chatzileontiadou D.S.M."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Chatzileontiadou D.S.M."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Lobos C.A."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Lobos C.A."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Szeto C."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/author | "Szeto C."xsd:string |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34685626 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |