DESCRIBE <http://purl.uniprot.org/citations/34697068>

Subject	Predicate	Object
http://purl.uniprot.org/citations/34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34697068	http://www.w3.org/2000/01/rdf-schema#comment	" Background/aim Opioid-binding protein/cell adhesion molecule-like (OPCML) plays a crucial role in the suppression of tumor progression in several cancer types. Nevertheless, the association between OPCML functions and cholangiocarcinoma (CCA) progression remains unknown. We aimed to investigate biological functions of OPCML and related signaling pathways in CCA cell lines. Materials and methods Methylation status and ectopic expression of OPCML were determined in CCA cell lines using methylation-specific polymerase chain reaction and pcDNA3.1+/C-(K)DYK-OPCML, respectively. Cell proliferation, migration and invasion were investigated. Results OPCML was found to be epigenetically silenced by DNA methylation. Ectopic expression of OPCML inhibited CCA proliferation by inducing apoptosis via AXL receptor tyrosine kinase/signal transducer and activator of transcription 3 (AXL/STAT3) inactivation. It also suppressed cell migration and invasion via down-regulation of Rho GTPases, ras homolog family member A (RHOA), Rac family small GTPase 1 (RAC1) and cell division cycle 42 (CDC42). Conclusion We are the first to unravel the antitumor effects and the related signaling pathways of OPCML in CCA. The loss of OPCML expression due to promoter hypermethylation can cause a decrease in cell death but increase in cell migration and invasion, which may at least in part contribute to CCA progression."xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.org/dc/terms/identifier	"doi:10.21873/cgp.20296"xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/author	"Settasatian C."xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/author	"Limpaiboon T."xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/author	"Daduang J."xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/author	"Khamko R."xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/date	"2021"xsd:gYear
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/name	"Cancer Genomics Proteomics"xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/pages	"771-780"xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/title	"OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3 Inactivation and Rho GTPase Down-regulation."xsd:string
http://purl.uniprot.org/citations/34697068	http://purl.uniprot.org/core/volume	"18"xsd:string
http://purl.uniprot.org/citations/34697068	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/34697068
http://purl.uniprot.org/citations/34697068	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/34697068
http://purl.uniprot.org/uniprot/#_A8K0Y0-mappedCitation-34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/#_B4DS15-mappedCitation-34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/#_B0AZR8-mappedCitation-34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/#_B2CZX3-mappedCitation-34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/#_B7ZLQ0-mappedCitation-34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/#_Q14982-mappedCitation-34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/#_Q6B0I4-mappedCitation-34697068	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/A8K0Y0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/Q14982	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/B2CZX3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34697068
http://purl.uniprot.org/uniprot/B7ZLQ0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34697068