DESCRIBE <http://purl.uniprot.org/citations/34704886>

Subject	Predicate	Object
http://purl.uniprot.org/citations/34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34704886	http://www.w3.org/2000/01/rdf-schema#comment	" Background Bladder cancer (BC) is one of the 10 most common types of cancer worldwide, with approximately 550,000 new cases each year. Early detection and appropriate diagnosis are important factors in successful treatment of the disease. Material and methods We used specific fluorogenic substrate for the quantitative determination of urine kallikrein 13 (KLK13) activity in healthy (n = 15) and BC (n = 54) patients. The proteolytic activity in individual urine samples was determined by fluorescence measurements. Then, immunoenzymatic analyses (ELISA, Western blot) were performed to confirm the presence of KLK13 in the tested samples. Results Urine samples from patients with G2 and G3 grade BC contained proteolytically active KLK13, as confirmed by kinetic analysis and immunochemical detection. KLK13 was not detected in the urine of patients with G1 grade BC. Discussion Previous clinical study reveals the KLK13 significance for BC prognosis as increased KLK13 expression was highlighted in bladder tumours compared to normal adjacent tissues. Our findings correlate to the report. KLK13 activity was confirmed in BC patients with G2 and G3 stage of disease development. Conclusions Using specific chromogenic/fluorogenic peptides could be useful for the non-invasive disease monitoring of BC progress."xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.org/dc/terms/identifier	"doi:10.1080/1354750x.2021.1999502"xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/author	"Lesner A."xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/author	"Rachubik P."xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/author	"Piwkowska A."xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/author	"Gruba N."xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/date	"2021"xsd:gYear
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/name	"Biomarkers"xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/pages	"770-779"xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/title	"Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer."xsd:string
http://purl.uniprot.org/citations/34704886	http://purl.uniprot.org/core/volume	"26"xsd:string
http://purl.uniprot.org/citations/34704886	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/34704886
http://purl.uniprot.org/citations/34704886	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/34704886
http://purl.uniprot.org/uniprot/#_A0A1R3UCE9-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/#_B5BUM9-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/#_M0R218-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/#_Q5BQ95-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/#_Q5BQ97-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/#_Q5BQ99-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/#_Q9UKR3-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/#_Q86VI7-mappedCitation-34704886	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/Q5BQ97	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/Q5BQ95	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34704886
http://purl.uniprot.org/uniprot/A0A1R3UCE9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34704886