| http://purl.uniprot.org/citations/34709360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34709360 | http://www.w3.org/2000/01/rdf-schema#comment | "The dynein motor performs multiple functions in mitosis by engaging with a wide cargo spectrum. One way to regulate dynein's cargo-binding selectivity is through the C-terminal domain (CTD) of its light intermediate chain 1 subunit (LIC1), which binds directly with cargo adaptors. Here we show that mitotic phosphorylation of LIC1-CTD at its three cdk1 sites is required for proper mitotic progression, for dynein loading onto prometaphase kinetochores, and for spindle assembly checkpoint inactivation in human cells. Mitotic LIC1-CTD phosphorylation also engages the prolyl isomerase Pin1 predominantly to Hook2-dynein-Nde1-Lis1 complexes, but not to dynein-spindly-dynactin complexes. LIC1-CTD dephosphorylation abrogates dynein-Pin1 binding, promotes prophase centrosome-nuclear envelope detachment, and impairs metaphase chromosome congression and mitotic Golgi fragmentation, without affecting interphase membrane transport. Phosphomutation of a conserved LIC1-CTD SP site in zebrafish leads to early developmental defects. Our work reveals that LIC1-CTD phosphorylation differentially regulates distinct mitotic dynein pools and suggests the evolutionary conservation of this phosphoregulation."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.202005184"xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/author | "Kumar C."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/author | "Kumar M."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/author | "Kumari A."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/author | "Mylavarapu S.V.S."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/author | "Mahale S.P."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/author | "Pergu R."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/author | "Wasnik N."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/pages | "e202005184"xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/title | "Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions."xsd:string |
| http://purl.uniprot.org/citations/34709360 | http://purl.uniprot.org/core/volume | "220"xsd:string |
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