| http://purl.uniprot.org/citations/34710355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34710355 | http://www.w3.org/2000/01/rdf-schema#comment | "Individual hosts within populations often show inter-individual variation in their susceptibility to bacterial pathogen-related diseases. Utilizing Drosophila, we highlight that phenotypic variation in host-pathogen susceptibility within populations is driven by energetic trade-offs, facilitated by infection-mediated changes in glutamate metabolism. Furthermore, host-pathogen susceptibility is conditioned by life history, which adjusts immunometabolic sensing in muscles to direct vitamin-dependent reallocation of host energy substrates from the adipose tissue (i.e., a muscle-adipose tissue axis). Life history conditions inter-individual variation in the activation strength of intra-muscular NF-κB signaling. Limited intra-muscular NF-κB signaling activity allows for enhanced infection-mediated mitochondrial biogenesis and function, which stimulates glutamate dehydrogenase-dependent synthesis of glutamate. Muscle-derived glutamate acts as a systemic metabolite to promote lipid mobilization through modulating vitamin B enzymatic cofactor transport and function in the adipose tissue. This energy substrate reallocation improves pathogen clearance and boosts host survival. Finally, life history events that adjust energetic trade-offs can shape inter-individual variation in host-pathogen susceptibility after infection."xsd:string |
| http://purl.uniprot.org/citations/34710355 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2021.10.003"xsd:string |
| http://purl.uniprot.org/citations/34710355 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/34710355 | http://purl.uniprot.org/core/author | "Karpac J."xsd:string |
| http://purl.uniprot.org/citations/34710355 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34710355 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
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| http://purl.uniprot.org/citations/34710355 | http://purl.uniprot.org/core/title | "Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/34710355 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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