| http://purl.uniprot.org/citations/34720844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34720844 | http://www.w3.org/2000/01/rdf-schema#comment | "The central complex is one of the major brain regions that control sleep in Drosophila. However, the circuitry details of sleep regulation have not been elucidated yet. Here, we show a novel sleep-regulating neuronal circuit in the protocerebral bridge (PB) of the central complex. Activation of the PB interneurons labeled by the R59E08-Gal4 and the PB columnar neurons with R52B10-Gal4 promoted sleep and wakefulness, respectively. A targeted GFP reconstitution across synaptic partners (t-GRASP) analysis demonstrated synaptic contact between these two groups of sleep-regulating PB neurons. Furthermore, we found that activation of a pair of dopaminergic (DA) neurons projecting to the PB (T1 DA neurons) decreased sleep. The wake-promoting T1 DA neurons and the sleep-promoting PB interneurons formed close associations. Dopamine 2-like receptor (Dop2R) knockdown in the sleep-promoting PB interneurons increased sleep. These results indicated that the neuronal circuit in the PB, regulated by dopamine signaling, mediates sleep-wakefulness."xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.org/dc/terms/identifier | "doi:10.3389/fnins.2021.647117"xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/author | "Kume K."xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/author | "Ban G."xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/author | "Kato Y.S."xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/author | "Tomita J."xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/name | "Front Neurosci"xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/pages | "647117"xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/title | "Protocerebral Bridge Neurons That Regulate Sleep in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/34720844 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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