| http://purl.uniprot.org/citations/34721959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34721959 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila extracellular matrix protein Dumpy (Dpy) is one of the largest proteins encoded by any animal. One class of dpy mutations produces a characteristic shortening of the wing blade known as oblique (dpyo ), due to altered tension in the developing wing. We describe here the characterization of docked (doc), a gene originally named because of an allele producing a truncated wing. We show that doc corresponds to the gene model CG5484, which encodes a homolog of the yeast protein Yif1 and plays a key role in ER to Golgi vesicle transport. Genetic analysis is consistent with a similar role for Doc in vesicle trafficking: docked alleles interact not only with genes encoding the COPII core proteins sec23 and sec13, but also with the SNARE proteins synaptobrevin and syntaxin. Further, we demonstrate that the strong similarity between the doc1 and dpyo wing phenotypes reflects a functional connection between the two genes; we found that various dpy alleles are sensitive to changes in dosage of genes encoding other vesicle transport components such as sec13 and sar1. Doc's effects on trafficking are not limited to Dpy; for example, reduced doc dosage disturbed Notch pathway signaling during wing blade and vein development. These results suggest a model in which the oblique wing phenotype in doc1 results from reduced transport of wild-type Dumpy protein; by extension, an additional implication is that the dpyo alleles can themselves be explained as hypomorphs."xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.org/dc/terms/identifier | "doi:10.7717/peerj.12175"xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/author | "Kandasamy S."xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/author | "Couto K."xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/author | "Thackeray J."xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/name | "PeerJ"xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/pages | "e12175"xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/title | "A docked mutation phenocopies dumpy oblique alleles via altered vesicle trafficking."xsd:string |
| http://purl.uniprot.org/citations/34721959 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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