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http://purl.uniprot.org/citations/34727153http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34727153http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Birdshot chorioretinopathy (BSCR) is strongly associated with HLA-A29. This study was designed to elucidate the genetic modifiers of BSCR in HLA-A29 carriers.

Methods

We sequenced the largest BSCR cohort to date, including 286 cases and 108 HLA-A29-positive controls to determine genome-wide common and rare variant associations. We further typed the HLA alleles of cases and 45,386 HLA-A29 controls of European ancestry to identify HLA alleles that associate with BSCR risk.

Results

Carrying a second allele that belongs to the HLA-Aw19 broad antigen family (including HLA-A29, -A30, -A31, and -A33) increases the risk for BSCR (odds ratio [OR] = 4.44; P = 2.2e-03). This result was validated by comparing allele frequencies to large HLA-A29-controlled cohorts (n = 45,386; OR > 2.5; P < 1.3e-06). We also confirm that ERAP1 and ERAP2 haplotypes modulate disease risk. A meta-analysis with an independent dataset confirmed that ERAP1 and ERAP2 haplotypes modulate the risk for disease at a genome-wide significant level: ERAP1-rs27432 (OR = 2.46; 95% confidence interval [CI], 1.85-3.26; P = 4.07e-10), an expression quantitative trait locus (eQTL) decreasing ERAP1 expression; and ERAP2-rs10044354 (OR = 1.95; 95% CI, 1.55-2.44; P = 6.2e-09), an eQTL increasing ERAP2 expression. Furthermore, ERAP2-rs2248374 that disrupts ERAP2 expression is protective (OR = 0.56; 95% CI, 0.45-0.70; P = 2.39e-07). BSCR risk is additively increased when combining ERAP1/ERAP2 risk genotypes with two copies of HLA-Aw19 alleles (OR = 13.53; 95% CI, 3.79-54.77; P = 1.17e-05).

Conclusions

The genetic factors increasing BSCR risk demonstrate a pattern of increased processing, as well as increased presentation of ERAP2-specific peptides. This suggests a mechanism in which exceeding a peptide presentation threshold activates the immune response in choroids of A29 carriers."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.org/dc/terms/identifier"doi:10.1167/iovs.62.14.3"xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Baras A."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Cooper B."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Coppola G."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Wolf S."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Bai X."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Kosmicki J.A."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Romano C."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Freudenberg J."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Ferreira M.A.R."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Stahl E.A."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Tabary T."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Overton J."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Brezin A."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Cohen J.H.M."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Monnet D."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Ligocki A.J."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Gelfman S."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Moscati A."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/author"Weyne J."xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/name"Invest Ophthalmol Vis Sci"xsd:string
http://purl.uniprot.org/citations/34727153http://purl.uniprot.org/core/pages"3"xsd:string
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