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http://purl.uniprot.org/citations/34727748http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34727748http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Insulin resistance (IR) is a key defect in type 2 diabetes mellitus (T2DM); therefore, effective means of ameliorating IR are sought.

Methods

We performed a retrospective cohort study of 154 patients with T2DM and 39 with pre-diabetes (pre-DM). The effects of IR and a high concentration of FFA on gene expression were determined using microarray analysis and quantitative reverse transcription polymerase chain reaction (RT-qPCR) in patients with T2DM or pre-DM.

Results

Serum FFA concentration and homeostasis model assessment of IR (HOMA-IR) were significantly higher in patients with T2DM but no obesity and in those with pre-DM than in controls. HOMA-IR was significantly associated with T2DM. RT-qPCR showed that the expression of FBJ murine osteosarcoma viral oncogene homolog (FOS) and AE binding protein 1 (AEBP1) was much lower in the circulation of participants with obesity and diabetes. RT-qPCR showed that the expression of docking protein 1 (DOK1) was significantly lower in the blood of participants with diabetes but no obesity and in those with pre-DM than in controls.

Conclusions

FFA and DOK1 are associated with IR in patients with T2DM but no obesity or pre-DM. The downregulation of DOK1 might inhibit lipid synthesis and induce lipolysis, inducing or worsening IR."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.org/dc/terms/identifier"doi:10.1177/03000605211048293"xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Cao H."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Cai X."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Li B."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Yang B."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Jiang R."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Xin Y."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/author"Ha X."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/name"J Int Med Res"xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/pages"3000605211048293"xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/title"Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus."xsd:string
http://purl.uniprot.org/citations/34727748http://purl.uniprot.org/core/volume"49"xsd:string
http://purl.uniprot.org/citations/34727748http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34727748
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