| http://purl.uniprot.org/citations/34729648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34729648 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the association of myosin heavy chain protein 11 (MYH11) and transforming growth factor β signaling-related gene polymorphisms with the susceptibility of DeBakey type III aortic dissection (AD) and its clinical outcomes. Four single-nucleotide polymorphism (SNPs) (MYH11 rs115364997, rs117593370, TGFB1 rs1800469, and TGFBR1 rs1626340) were analyzed in patients with DeBakey III AD (173) and healthy participants (335). Gene-gene and gene-environment interactions were evaluated using generalized multifactor dimensionality reduction. The patients were followed up for a median of 55.7 months. MYH11 rs115364997 G or TGFBR1 rs1626340 A carriers had an increased risk of DeBakey type III AD. MYH11, TGFB1, TGFBR1, and environment interactions contributed to the risk of DeBakey type III AD (cross-validation consistency = 10/10, P = 0.001). Dominant models of MYH11 rs115364997 AG + GG genotype (HR = 2.443; 95%CI: 1.096-5.445, P = 0.029), TGFB1 rs1800469 AG + GG (HR = 2.303; 95%CI: 1.069-4.96, P = 0.033) were associated with an increased risk of mortality in DeBakey type III AD. The dominant model of TGFB1 rs1800469 AG + GG genotype was associated with an increased risk of recurrence of chest pain in DeBakey type III AD (HR = 1.566; 95%CI: 1.018-2.378, P = 0.041). In conclusions, G carriers of MYH11 rs115364997 or TGFB1 rs1800469 may be the poor prognostic indicators of mortality and recurrent chest pain in DeBakey type III AD. The interactions of gene-gene and gene-environment are associated with the risk of DeBakey type III AD."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00335-021-09929-6"xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/author | "Jiang P."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/author | "Yuan Q."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/author | "Chang Y."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/name | "Mamm Genome"xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/pages | "555-563"xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/title | "Association of gene polymorphisms in MYH11 and TGF-beta signaling with the susceptibility and clinical outcomes of DeBakey type III aortic dissection."xsd:string |
| http://purl.uniprot.org/citations/34729648 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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