Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/34730391http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34730391http://www.w3.org/2000/01/rdf-schema#comment"Zika virus (ZIKV) belongs to mosquito-borne flaviviruses. Unlike other members in the family, ZIKV can be sexually transmitted, and the female genital tracts are susceptible to ZIKV. However, the impact of ZIKV infection on nonpregnant female reproductive health is not understood. In this study, we investigated the effects of ZIKV infection on the ovary by using nonpregnant female interferon α/β receptor-deficient (Ifnar1-/-) mice. The results showed that the ovary supported ZIKV replication, and the granulosa and theca cells of antral follicles were susceptible. ZIKV replication in situ significantly reduced the numbers of antral follicles, aggravated follicular atresia, and disrupted folliculogenesis. Notably, ZIKV replication in the ovary caused disordered ovarian steroidogenesis manifested by decreased expression of key enzymes linked to sex hormone synthesis, including the cytochrome P450 17A1 (CYP17A1) and aromatase (CYP19A1). Further, we observed that ZIKV infection disrupted the estrous cycle and thus prolonged the time to conceive. More importantly, although ZIKV RNA could not be detected at 3 months postinfection, damaged ovarian structure and dysfunction were also observed. Taken together, our study demonstrates that ZIKV infection in nonpregnant female mice cause ovarian damage and dysfunction, even long after ZIKV clearance. These data provide important information to understand the effects of ZIKV infection in female reproductive tissues and basic evidence for further studies. IMPORTANCE Zika virus (ZIKV), a flavivirus, is primarily transmitted by mosquito bites. But it can also be transmitted vertically and sexually. Although ZIKV-associated Guillain-Barré syndrome and microcephaly have drawn great attention, there have been few studies on the potential effects of ZIKV on the genital tract of nonpregnant females. This study investigated the effects of ZIKV on the ovaries in mice. We found that ZIKV replicated in the ovary and the granulosa and theca cells of antral follicles were susceptible. ZIKV replication in situ significantly damaged ovarian structure and function and disrupted folliculogenesis. Notably, ZIKV infection further disrupted the estrous cycle and prolonged the time to conceive in mice by causing disordered ovarian steroidogenesis. These effects were observed in both the acute phase and the recovery phase after viral elimination. Overall, the new findings provide important additions to make out the potential adverse impacts of ZIKV on reproductive health in females."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.org/dc/terms/identifier"doi:10.1128/jvi.01189-21"xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"An J."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Fan D."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Wu N."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Wang P."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Zhou D."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Gao N."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Cheng G."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/author"Sheng Z."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/name"J Virol"xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/pages"e0118921"xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/title"Zika Virus Infection in the Ovary Induces a Continuously Elevated Progesterone Level and Compromises Conception in Interferon Alpha/Beta Receptor-Deficient Mice."xsd:string
http://purl.uniprot.org/citations/34730391http://purl.uniprot.org/core/volume"96"xsd:string
http://purl.uniprot.org/citations/34730391http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34730391
http://purl.uniprot.org/citations/34730391http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34730391
http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-34730391http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34730391
http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-34730391http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34730391
http://purl.uniprot.org/uniprot/#_A0A338P6X7-mappedCitation-34730391http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34730391
http://purl.uniprot.org/uniprot/#_A0A384DVB8-mappedCitation-34730391http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34730391
http://purl.uniprot.org/uniprot/#_E9PWM1-mappedCitation-34730391http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34730391
http://purl.uniprot.org/uniprot/#_E9PX11-mappedCitation-34730391http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34730391
▶