| http://purl.uniprot.org/citations/34731623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34731623 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human lung adenocarcinoma cells remain largely unknown. Here, we identify FARP1, ARHGEF39, and TIAM2 as essential Rac-GEFs responsible for Rac1-mediated lung cancer cell migration upon EGFR and c-Met activation. Noteworthily, these Rac-GEFs operate in a non-redundant manner by controlling distinctive aspects of ruffle dynamics formation. Mechanistic analysis reveals a leading role of the AXL-Gab1-PI3K axis in conferring pro-motility traits downstream of EGFR. Along with the positive association between the overexpression of Rac-GEFs and poor lung adenocarcinoma patient survival, we show that FARP1 and ARHGEF39 are upregulated in EpCam+ cells sorted from primary human lung adenocarcinomas. Overall, our study reveals fundamental insights into the complex intricacies underlying Rac-GEF-mediated cancer cell motility signaling, hence underscoring promising targets for metastatic lung cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109905"xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Baker M.J."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Kazanietz M.G."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Garcia-Mata R."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Cooke M."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Abba M.C."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Goicoechea S.M."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Eruslanov E."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Kreider-Letterman G."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/author | "Sullivan N.T."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/pages | "109905"xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/title | "FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/34731623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34731623 |
| http://purl.uniprot.org/citations/34731623 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34731623 |
| http://purl.uniprot.org/uniprot/#_A0A2X0SFC2-mappedCitation-34731623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34731623 |
| http://purl.uniprot.org/uniprot/#_A0A2X0TVY0-mappedCitation-34731623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34731623 |
| http://purl.uniprot.org/uniprot/#_B3KW11-mappedCitation-34731623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34731623 |
| http://purl.uniprot.org/uniprot/#_B4E0T1-mappedCitation-34731623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34731623 |
| http://purl.uniprot.org/uniprot/#_B7Z624-mappedCitation-34731623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34731623 |