| http://purl.uniprot.org/citations/34732825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34732825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34732825 | http://www.w3.org/2000/01/rdf-schema#comment | "Poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerases (PARPs) is one of the immediate cellular responses to DNA damage. The histone PARylation factor 1 (HPF1) discovered recently to form a joint active site with PARP1 and PARP2 was shown to limit the PARylation activity of PARPs and stimulate their NAD+-hydrolase activity. Here we demonstrate that HPF1 can stimulate the DNA-dependent and DNA-independent autoPARylation of PARP1 and PARP2 as well as the heteroPARylation of histones in the complex with nucleosome. The stimulatory action is detected in a defined range of HPF1 and NAD+ concentrations at which no HPF1-dependent enhancement in the hydrolytic NAD+ consumption occurs. PARP2, comparing with PARP1, is more efficiently stimulated by HPF1 in the autoPARylation reaction and is more active in the heteroPARylation of histones than in the automodification, suggesting a specific role of PARP2 in the ADP-ribosylation-dependent modulation of chromatin structure. Possible role of the dual function of HPF1 in the maintaining PARP activity is discussed."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-021-02780-0"xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-021-02780-0"xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Lavrik O.I."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Lavrik O.I."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Kurgina T.A."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Kurgina T.A."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Kutuzov M.M."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Kutuzov M.M."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Moor N.A."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Moor N.A."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Naumenko K.N."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Naumenko K.N."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Ukraintsev A.A."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/author | "Ukraintsev A.A."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/name | "Commun. Biol."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/name | "Commun. Biol."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/pages | "1259"xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/pages | "1259"xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/title | "Dual function of HPF1 in the modulation of PARP1 and PARP2 activities."xsd:string |
| http://purl.uniprot.org/citations/34732825 | http://purl.uniprot.org/core/title | "Dual function of HPF1 in the modulation of PARP1 and PARP2 activities."xsd:string |