| http://purl.uniprot.org/citations/34733286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34733286 | http://www.w3.org/2000/01/rdf-schema#comment | "The autonomic nervous system has been studied for its involvement in the control of macrophages; however, the mechanisms underlying the interaction between the adrenergic receptors and alternatively activated macrophages (M2) remain obscure. Using FVB wild-type and beta 2 adrenergic receptors knockout, we found that β2-AR deficiency alleviates hepatobiliary damage in mice infected with C. sinensis. Moreover, β2-AR-deficient mice decrease the activation and infiltration of M2 macrophages and decrease the production of type 2 cytokines, which are associated with a significant decrease in liver fibrosis in infected mice. Our in vitro results on bone marrow-derived macrophages revealed that macrophages from Adrb2-/- mice significantly decrease M2 markers and the phosphorylation of ERK/mTORC1 induced by IL-4 compared to that observed in M2 macrophages from Adrb2+/+ . This study provides a better understanding of the mechanisms by which the β2-AR enhances type 2 immune response through the ERK/mTORC1 signaling pathway in macrophages and their role in liver fibrosis."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.754208"xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Yu Q."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Wang J.L."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Zhou Q.Y."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Li X.Y."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Chen J.X."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Liu J.X."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Xu Y.H."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Lv Z.Y."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Zheng K.Y."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Koda S."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Tang R.X."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Adzika G.K."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/author | "Tekengne B.O.T."xsd:string |
| http://purl.uniprot.org/citations/34733286 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |