| http://purl.uniprot.org/citations/34734460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34734460 | http://www.w3.org/2000/01/rdf-schema#comment | "Constitutive NF-κB activation is associated with cellular senescence and stem cell dysfunction and rare variants in NF-κB family members are enriched in centenarians. We recently identified a novel small molecule (SR12343) that inhibits IKK/NF-κB activation by disrupting the association between IKKβ and NEMO. Here we investigated the therapeutic effects of SR12343 on senescence and aging in three different mouse models. SR12343 reduced senescence-associated beta-galactosidase (SA-β-gal) activity in oxidative stress-induced senescent mouse embryonic fibroblasts as well as in etoposide-induced senescent human IMR90 cells. Chronic administration of SR12343 to the Ercc1-/∆ and Zmpste24-/- mouse models of accelerated aging reduced markers of cellular senescence and SASP and improved multiple parameters of aging. SR12343 also reduced markers of senescence and increased muscle fiber size in 2-year-old WT mice. Taken together, these results demonstrate that IKK/NF-κB signaling pathway represents a promising target for reducing markers of cellular senescence, extending healthspan and treating age-related diseases."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.org/dc/terms/identifier | "doi:10.1111/acel.13486"xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Mu X."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "McGowan S.J."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Suh Y."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Sakamoto A."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Yousefzadeh M.J."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Niedernhofer L.J."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Robbins P.D."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Kamenecka T.M."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "LeBrasseur N.K."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Huard J."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Angelini L."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "Aversa Z."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/author | "O'Kelly R.D."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/pages | "e13486"xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/title | "Novel small molecule inhibition of IKK/NF-kappaB activation reduces markers of senescence and improves healthspan in mouse models of aging."xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/34734460 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34734460 |
| http://purl.uniprot.org/citations/34734460 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34734460 |