| http://purl.uniprot.org/citations/34738847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34738847 | http://www.w3.org/2000/01/rdf-schema#comment | "Background: Cytogenetics at diagnosis is the most important prognostic factor for adult acute myeloid leukemia (AML), but nearly 50% of AML patients who exhibit cytogenetically normal AML (CN-AML) do not undergo effective risk stratification. Therefore, the development of potential biomarkers to further define risk stratification for CN-AML patients is worth exploring. Methods: Transcriptome data from 163 cases in the GSE12417-GPL96 dataset and 104 CN-AML patient cases in the GSE71014-GPL10558 dataset were downloaded from the Gene Expression Omnibus database for overall survival (OS) analysis and validation. Results: The combination of Wilms tumor 1 (WT1) and cluster of diffraction 58 (CD58) can predict the prognosis of CN-AML patients. High expression of WT1 and low expression of CD58 were associated with poor OS in CN-AML. Notably, when WT1 and CD58 were used to concurrently predict OS, CN-AML patients were divided into three groups: low risk, WT1lowCD58high; intermediate risk, WT1highCD58high or WT1lowCD58low; and high risk, WT1highCD58low. Compared with low-risk patients, intermediate- and high-risk patients had shorter survival time and worse OS. Furthermore, a nomogram model constructed with WT1 and CD58 may personalize and reveal the 1-, 2-, 3-, 4-, and 5-year OS rate of CN-AML patients. Both time-dependent receiver operating characteristics and calibration curves suggested that the nomogram model demonstrated good performance. Conclusion: Higher expression of WT1 with lower CD58 expression may be a potential biomarker for risk stratification of CN-AML patients. Moreover, a nomogram model constructed with WT1 and CD58 may personalize and reveal the 1-, 2-, 3-, 4-, and 5-year OS rates of CN-AML patients."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.org/dc/terms/identifier | "doi:10.1177/15330338211052152"xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Jin Z."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Chio C.L."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/author | "Li Y.'"xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/name | "Technol Cancer Res Treat"xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/pages | "15330338211052152"xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/title | "Higher Expression of WT1 With Lower CD58 Expression may be Biomarkers for Risk Stratification of Patients With Cytogenetically Normal Acute Myeloid Leukemia."xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/34738847 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34738847 |
| http://purl.uniprot.org/citations/34738847 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34738847 |
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| http://purl.uniprot.org/uniprot/#_A0FJ57-mappedCitation-34738847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34738847 |
| http://purl.uniprot.org/uniprot/#_A0FJ58-mappedCitation-34738847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34738847 |
| http://purl.uniprot.org/uniprot/#_A0A481V744-mappedCitation-34738847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34738847 |