| http://purl.uniprot.org/citations/34752634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34752634 | http://www.w3.org/2000/01/rdf-schema#comment | "Overwhelming activation of T cells in acute malaria is associated with severe outcomes. Thus, counter-regulation by anti-inflammatory mechanisms is indispensable for an optimal resolution of disease. Using Plasmodium berghei ANKA (PbA) infection of C57BL/6 mice, we performed a comprehensive analysis of co-inhibitory molecules expressed on CD4+ and CD8+ T cells using an unbiased cluster analysis approach. We identified similar T cell clusters co-expressing several co-inhibitory molecules like programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 (LAG-3) in the CD4+ and the CD8+ T cell compartment. Interestingly, despite expressing co-inhibitory molecules, which are associated with T cell exhaustion in chronic settings, these T cells were more functional compared to activated T cells that were negative for co-inhibitory molecules. However, T cells expressing high levels of PD-1 and LAG-3 also conferred suppressive capacity and thus resembled type I regulatory T cells. To our knowledge, this is the first description of malaria-induced CD8+ T cells with suppressive capacity. Importantly, we found an induction of T cells with a similar co-inhibitory rich phenotype in Plasmodium falciparum-infected patients. In conclusion, we demonstrate that malaria-induced T cells expressing co-inhibitory molecules are not exhausted, but acquire additional suppressive capacity, which might represent an immune regulatory pathway to prevent further activation of T cells during acute malaria."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.202149424"xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Lehmann C."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Jacobs T."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Addo M."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Ramharter M."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Schulze Zur Wiesch J."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Riehn M."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Brandi J."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Kaminski L.C."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/author | "Mackroth M."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/pages | "312-327"xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/title | "T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice."xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/34752634 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34752634 |
| http://purl.uniprot.org/citations/34752634 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34752634 |
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| http://purl.uniprot.org/uniprot/#_P18627-mappedCitation-34752634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34752634 |
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| http://purl.uniprot.org/uniprot/#_Q86TL7-mappedCitation-34752634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34752634 |
| http://purl.uniprot.org/uniprot/#_Q15116-mappedCitation-34752634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34752634 |
| http://purl.uniprot.org/uniprot/#_Q544F3-mappedCitation-34752634 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34752634 |