| http://purl.uniprot.org/citations/34752747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34752747 | http://www.w3.org/2000/01/rdf-schema#comment | "Although gene expression is tightly regulated during embryonic development, the impact of translational control has received less experimental attention. Here, we find that eukaryotic translation initiation factor-3 (eIF3) is required for Shh-mediated tissue patterning. Analysis of loss-of-function eIF3 subunit c (Eif3c) mice reveal a unique sensitivity to the Shh receptor patched 1 (Ptch1) dosage. Genome-wide in vivo enhanced cross-linking immunoprecipitation sequence (eCLIP-seq) shows unexpected specificity for eIF3 binding to a pyrimidine-rich motif present in subsets of 5'-UTRs and a corresponding change in the translation of these transcripts by ribosome profiling in Eif3c loss-of-function embryos. We further find a transcript specific effect in Eif3c loss-of-function embryos whereby translation of Ptch1 through this pyrimidine-rich motif is specifically sensitive to eIF3 amount. Altogether, this work uncovers hidden specificity of housekeeping translation initiation machinery for the translation of key developmental signaling transcripts."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2021.10.009"xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/author | "Fujii K."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/author | "Kerr C.H."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/author | "Walsh E.M."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/author | "Barna M."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/author | "Byeon G.W."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/author | "Zhulyn O."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/author | "Genuth N.R."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/pages | "2928-2937.e9"xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/title | "Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c."xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/34752747 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34752747 |
| http://purl.uniprot.org/citations/34752747 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34752747 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-34752747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34752747 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-34752747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34752747 |
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