| http://purl.uniprot.org/citations/34758313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34758313 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms of Myc-driven liver tumorigenesis are inadequately understood. Herein we show that Myc-driven hepatocellular carcinoma (HCC) is dramatically aggravated in mice with hepatocyte-specific Ptpn11/Shp2 deletion. However, Myc-induced tumors develop selectively from the rare Shp2-positive hepatocytes in Shp2-deficent liver, and Myc-driven oncogenesis depends on an intact Ras-Erk signaling promoted by Shp2 to sustain Myc stability. Despite a stringent requirement of Shp2 cell autonomously, Shp2 deletion induces an immunosuppressive environment, resulting in defective clearance of tumor-initiating cells and aggressive tumor progression. The basal Wnt/β-catenin signaling is upregulated in Shp2-deficient liver, which is further augmented by Myc transfection. Ablating Ctnnb1 suppresses Myc-induced HCC in Shp2-deficient livers, revealing an essential role of β-catenin. Consistently, Myc overexpression and CTNNB1 mutations are frequently co-detected in HCC patients with poor prognosis. These data elucidate complex mechanisms of liver tumorigenesis driven by cell-intrinsic oncogenic signaling in cooperation with a tumor-promoting microenvironment generated by disrupting the specific oncogenic pathway."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109974"xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Kaneko K."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Liu J.J."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Chen W.S."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Feng G.S."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Zong M."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/author | "Hanley K.L."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/pages | "109974"xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/title | "Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment."xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/34758313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34758313 |
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